Development of Calorie Restriction Mimetics as a Prolongevity Strategy
نویسندگان
چکیده
منابع مشابه
Glycolytic inhibition as a strategy for developing calorie restriction mimetics.
Calorie restriction (CR) remains the most robust environmental intervention for altering aging processes and increasing healthspan and lifespan. Emerging from progress made in many nonhuman models, current research has expanded to formal, controlled human studies of CR. Since long-term CR requires a major commitment of will power and long-term negative consequences remain to be determined, the ...
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The effects of calorie restriction without malnutrition seem to possess many beneficial effects in numerous disease states. Recently, studies related to calorie restriction mimetics that biochemically mimic the effects of calorie restriction are also becoming increasingly popular. Both calorie restriction and calorie restriction mimetics trigger an adaptive response reminiscent of mild-stress o...
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Calorie restriction (CR) is the most robust intervention that decreases morbidity and mortality, and thereby increases the lifespan of many organisms. Although the signaling pathways involved in the beneficial effects of CR are not yet fully understood. Several candidate pathways and key molecules have been identified. The effects of CR are highly conserved from lower organisms such as yeast to...
متن کاملCalorie Restriction Mimetics: Examples and Mode of Action
The search for Calorie Restriction Mimetics (CRM) compounds that mimic the genetic, biochemical and physical actions of calorie restriction is not a search for a ‘lazy dieters pill’. It is a quest aiming to clarify the basic mechanisms of calorie restriction and develop strategies in order to prevent, treat or alleviate age-related conditions. The development of CRM will add new and important a...
متن کاملCalorie restriction as an intervention in ageing
Ageing causes loss of function in tissues and organs, is accompanied by a chronic inflammatory process and affects life- and healthspan. Calorie restriction (CR) is a non-genetic intervention that prevents age-associated diseases and extends longevity in most of the animal models studied so far. CR produces a pleiotropic effect and improves multiple metabolic pathways, generating benefits to th...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2004
ISSN: 0077-8923,1749-6632
DOI: 10.1196/annals.1297.074